Longitudinal PACC Analyses

The following analyses are re-run versions of our previously found significant results, but this time only including participants from A4 and LEARN (not including participants who screen failed and don’t have longitudinal data). There are very minor differences between the analyses (110 gene x sex x ab results significant instead of 118).

Significant Results Table

Summary table of all significant results (after fdr correction) from the following longitudinal PACC analyses:

1. PACC ~ GeneExp*Sex*E4
2. PACC ~ GeneExp*Ab
3. PACC ~ GeneExp*Sex*Ab
4. PACC ~ GeneExp*p-tau217 (still need to run)

Analyses

All models are adjusted for sex, baseline age, years of education, cohort/treatment (A4 Placebo, A4 Treated, LEARN/SF), PACC story version, and cumulative dose. PACC story version and cumulative dose are time varying variables.

PACC ~ Gene x Sex x APOEe4

There is 1 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

ENSG00000211745

PACC ~ Gene x Amyloid

There are 6 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

Plots of select significant genes

ENSG00000115942

ENSG00000240132

PACC ~ Gene x Sex x Amyloid

There are 110 significant gene that survives FDR correction.

Volcano Plot

Summary Table

Significant Results Plots

Plots of select significant genes

ENSG00000176371

ENSG00000163082

PACC ~ Gene x p-tau

Still need to run